Journal: Nature Communications
Article Title: Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease
doi: 10.1038/s41467-025-59172-9
Figure Lengend Snippet: a Volcano plot of the differentially expressed genes (DEGs) of the colon tissues in the colitic water group and the EcN/CO@HAD group. b Gene ontology (GO) enrichment analysis of the DEGs in the colitic water group and the EcN/CO@HAD group associated with inflammatory response. c PPI network analysis of immune cell activities. GO enrichment analysis of the DEGs in the colitic water group and the EcN/CO@HAD group associated with ( d ) cellular biosynthesis and metabolism and ( e ) cell proliferation. f PPI network analysis of metabolism and cell proliferation. g Kyoto Encyclopedia of Gene and Genomes (KEGG) analysis of the DEGs in the transcriptome map. The horizontal axis represents gene ratio, the vertical axis represents gene term, and the bubble size represents the enriched gene counts. The P values were determined using the negative binomial distribution, and then the Bonferroni was used for multiple-hypothesis testing correction. Source data are provided as a Source Data file.
Article Snippet: RNA-seq transcriptome libraries were prepared following TruSeq TM RNA sample preparation Kit from Illumina (San Diego, CA), using 1 μg of total RNA.
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